Chemokine Requirements for B Cell Entry to Lymph Nodes and Peyer's Patches

Trafficking Across High Endothelial Venules Peyer's Patches and Affects B Cell Endothelial Venules of Lymph Nodes and Chemoattractant Is Expressed in the High Chemokine Ligand 13/B Lymphocyte Cutting Edge: The B Cell Chemokine CXC

SnapShot: Cytokines III

Inflammatory; promotes activation and production of acute-phase proteins ↓ = disregulated fever; increased susceptibility to bacterial infection; enhanced resistance to LPS-induced septic shock ↑ = exacerbation of arthritis and colitis T cells, B cells Many cell types Promotes activation and cytotoxicity; development of lymph nodes and Peyer's patches ↓ = defective response to bacterial pathoge...

A Putative Chemokine Receptor, BLR1, Directs B Cell Migration to Defined Lymphoid Organs and Specific Anatomic Compartments of the Spleen

We describe the phenotype of gene-targeted mice lacking the putative chemokine receptor BLR1. In normal mice, this receptor is expressed on mature B cells and a subpopulation of T helper cells. Blr1 mutant mice lack inguinal lymph nodes and possess no or only a few phenotypically abnormal Peyer's patches. The migration of lymphocytes into splenic follicles is severely impaired, resulting in mor...

Defective Peyer's patch organogenesis in mice lacking the 55-kD receptor for tumor necrosis factor

Lymphotoxin alpha (LT-alpha) may form secreted homotrimers binding to p55 and p75 tumor necrosis factor (TNF) receptors or cell surface-bound heterotrimers with LT-beta that interact with the LT-beta receptor. Genetic ablation of LT-alpha revealed that mutant mice have no detectable lymph nodes or Peyer's patches and that the organization of the splenic white pulp in T and B cell areas is distu...

Brief Definitive Report Defective Peyer's Patch Organogenesis in Mice Lacking the 55-kD Receptor for Tumor Necrosis Factor

Lymphotoxin ot (LT-cx) may form secreted homotrimers binding to p55 and p75 tumor necrosis factor (TNF) receptors or cell surface-bound heterotrimers with LT-[3 that interact with the LT-[3 receptor. Genetic ablation of LT-ot revealed that mutant mice have no detectable lymph nodes or Peyer's patches and that the organization of the splenic white pulp in T and B cell areas is disturbed. In this...